The genomic and epidemiological dynamics of human influenza A virus
Identifieur interne : 001303 ( Main/Exploration ); précédent : 001302; suivant : 001304The genomic and epidemiological dynamics of human influenza A virus
Auteurs : Andrew Rambaut [Royaume-Uni, États-Unis] ; Oliver G. Pybus [Royaume-Uni] ; Martha I. Nelson [États-Unis] ; Cecile Viboud [États-Unis] ; Jeffery K. Taubenberger [États-Unis] ; Edward C. Holmes [États-Unis]Source :
- Nature [ 0028-0836 ] ; 2008-05-29.
Abstract
The evolutionary interaction between influenza A virus and the human immune system, manifest as ‘antigenic drift’ of the viral haemagglutinin, is one of the best described patterns in molecular evolution. However, little is known about the genome-scale evolutionary dynamics of this pathogen. Similarly, how genomic processes relate to global influenza epidemiology, in which the A/H3N2 and A/H1N1 subtypes co-circulate, is poorly understood. Here through an analysis of 1,302 complete viral genomes sampled from temperate populations in both hemispheres, we show that the genomic evolution of influenza A virus is characterized by a complex interplay between frequent reassortment and periodic selective sweeps. The A/H3N2 and A/H1N1 subtypes exhibit different evolutionary dynamics, with diverse lineages circulating in A/H1N1, indicative of weaker antigenic drift. These results suggest a sink–source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir, which we hypothesize to be located in the tropics, to sink populations in temperate regions.
Url:
- https://api.istex.fr/ark:/67375/GT4-LXS1T56H-J/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441973
DOI: 10.1038/nature06945
Affiliations:
- Royaume-Uni, États-Unis
- Angleterre, Oxfordshire, Pennsylvanie, Écosse
- Oxford, University Park (Pennsylvanie), Édimbourg
- Université d'Oxford, Université d'Édimbourg, Université d'État de Pennsylvanie
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Le document en format XML
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Pybus</name></country><country name="États-Unis"><noRegion><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name></noRegion><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. Holmes</name><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. Holmes</name><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. Holmes</name><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I." last="Nelson">Martha I. Nelson</name><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name><name sortKey="Viboud, Cecile" sort="Viboud, Cecile" uniqKey="Viboud C" first="Cecile" last="Viboud">Cecile Viboud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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